Cymene and Dominic talk drone dreams, disappearing glaciers and boring sagas and then (13:07) the wonderful Sophia Roosth (Harvard, History of Science) joins the pod to talk about, among other things, her excellent new book, Synthetic: How Life Got Made (U Chicago Press, 2017). We begin with synthetic biology, where it came from and what counts as “life” and what counts as “making” in the field. We then discuss how synthetic biologists think their way between creation, construction, and design, the noise and signal of life, exegesis as an evolutionary force, whether genetically modified organisms are queer lifeforms, and how synthetic biology and maker culture intersected in the amateur DIY bio community. We talk about intellectual property, venture capital and how bioengineering came to be captured by the logic of industrial capitalism. We turn from there to bioterror and why synthetic biology doesn’t make Sophia’s top ten list of things to be scared about. We cover biological salvage and deextinction experiments like Pleistocene Park and Sophia explains how synthetic biology has unsettled scientific understandings of “species.” Finally we hear a bit about her fascinating new work with geobiologists on the origins of life. Listen on!